David De Gea and Luke Shaw will be with the squad for the crucial match in Germany but Solskjaer has confirmed Anthony Martial and Edinson Cavani will not be making the trip.
They both hobbled off in the 3-1 win against West Ham in the Premier League at the weekend.
“David De Gea is travelling, Luke Shaw is travelling,” Solskjaer said.
“Edinson and Anthony only minor niggles, but won’t be making the trip.”
RB Leipzig will be without highly-rated centre-back Dayot Upamecano as he is suspended after picking up three yellow cards.
Leipzig defenders Lukas Klostermann and Benjamin Henrichs are injury doubts for the crunch matchday six clash.
Julian Nagelsmann’s side will be confident after the 3-3 draw with Bayern Munich at the weekend which leaves them third in the Bundesliga.
United will hope to repeat what they did at Old Trafford in the reverse fixture and book their place in the knockout rounds.
Man Utd squad to face RB Leipzig
Goalkeepers: David De Gea, Dean Henderson, Lee Grant.
Defenders: Eric Bailly, Tim Fosu-Mensah, Victor Lindelof, Harry Maguire, Luke Shaw, Alex Telles, Axel Tuanzebe, Aaron Wan-Bissaka, Brandon Williams.
Midfielders: Bruno Fernandes, Daniel James, Jesse Lingard, Juan Mata, Nemanja Matic, Scott McTominay, Paul Pogba, Donny van de Beek.
Forwards: Odion Ighalo, Mason Greenwood, Marcus Rashford.
Published at Mon, 07 Dec 2020 14:15:00 +0000